PN-HPT^® (Polynucleotides Highly Purified Technology) in facial middle third rejuvenation. Exploring the potential

Wasting of soft tissues leads to flattening and deflation of the aging midface skin. Polynucleotides Highly Purified Technology (PN-HPT^® ) demonstrated dermal hydration and elasticity as well as fibroblasts vitality and activity.

To probe the value of PN-HPT^® in middle third rejuvenation in an open-design, exploratory prospective cohort study in 40 real-life ambulatorily treated women.

Three treatment sessions-at baseline (2-ml prefilled syringe containing 10 mg/ml PN-HPT^® , 10 mg/ml hyaluronic acid, 200 mM mannitol) as intradermic gel, and after 3 weeks (2-ml prefilled syringe containing 20 mg/ml PN-HPT^® intradermic gel) and 6 weeks (same treatment as baseline). The protocol allowed supplemental treatment with specifically formulated PN-HPT^® (7.5 mg/ml) when needed in periocular and eyelid areas.

sequential photographs of the facial middle third at baseline, third treatment session and 6-8 weeks after the third treatment session; scoring of overall skin quality and texture, skin quality determinants (wrinkles and skin roughness, skin elasticity, skin brightness), scar appearance, and subjective satisfaction with impromptu 10-cm Visual Analogue Scales.

Significant improvement of overall skin quality and texture (from 7.0 ± 1.06 at baseline session to 7.8 ± 0.99 at follow-up), associated with highly significant improvements of wrinkles and skin roughness, elasticity, and brightness (-17.1%, +39.6%, and +51.1%, respectively). The severity scores of post-acne scars decreased from 7.6 ± 1.32 to 4.2 ± 2.13. Individual satisfaction score at the end of treatment: 0.8 ± 0.28.

PN-HPT^® candidate as a valuable option for facial middle third rejuvenation. Further trials will hopefully confirm these early results.