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Outcome of drug resistant tuberculosis in Indian children

Naman S Shetty1, Minnie Bodhanwala2, Ira Shah1

  • 1Pediatric TB Clinic, Department of Pediatric Infectious Diseases, 30194BJ Wadia Hospital for Children, Mumbai, India.

Tropical Doctor
|November 18, 2021
PubMed

Insights

Drug-resistant tuberculosis (DR-TB) in children shows high treatment success and low fatality rates. While adverse drug reactions are common, they are typically reversible, indicating manageable treatment outcomes.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global health challenge, particularly drug-resistant strains.
  • Pediatric drug-resistant tuberculosis (DR-TB) presents unique management and outcome challenges.
  • Limited data exists on the treatment outcomes for bacteriologically confirmed DR-TB in children.

Purpose of the Study:

  • To determine the treatment outcomes of children diagnosed with bacteriologically confirmed drug-resistant tuberculosis (DR-TB).
  • To assess the safety and tolerability of DR-TB treatment regimens in a pediatric population.

Main Methods:

  • Retrospective analysis of 174 pediatric cases with bacteriologically confirmed DR-TB.
  • Evaluation of treatment completion rates, fatality incidence, and treatment failure.
  • Monitoring and documentation of adverse drug reactions during therapy.

Main Results:

  • High treatment completion rates were observed in children with DR-TB.
  • Low incidence of fatality and treatment failure was reported.
  • Reversible adverse drug reactions were frequently encountered during the treatment course.

Conclusions:

  • Bacteriologically confirmed DR-TB in children can achieve favorable outcomes with high treatment completion rates.
  • Despite common reversible adverse drug reactions, DR-TB treatment in pediatric patients appears manageable.
  • These findings support the importance of early diagnosis and consistent management of DR-TB in children.

Keywords:
Adverse drug reactioncompliancecomplicationresponsetreatment

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