Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Oct 13, 2025

Author Spotlight: Innovative Methodology for Implanting and Securing Neural Probes in the Rodent Spinal Cord

Author Spotlight: Innovative Methodology for Implanting and Securing Neural Probes in the Rodent Spinal Cord

Published on: July 12, 2024

What does an explanted PASCAL device look like?

Mathias Van Hemelrijck¹, Juri Sromicki¹, Martin O Schmiady¹

¹Clinic for Cardiac Surgery, University Hospital Zurich, Zurich, Switzerland.

Interactive Cardiovascular and Thoracic Surgery

|November 18, 2021

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tricuspid valve repair in infective endocarditis.

Annals of cardiothoracic surgery·2026

Same author

Mind the Gap: Inadequate Performance of Embolic Risk Scores in Infective Endocarditis.

Open forum infectious diseases·2026

Same author

Establishment of an MR-Conditional Porcine Model for Real-Time Assessment of Cerebral Blood Flow During Extracorporeal Circulation.

Journal of cardiovascular development and disease·2026

Same author

The 2025 Accra Declaration on Upskilling and Cost- Effective Cardiac Surgery in Africa.

Asian cardiovascular & thoracic annals·2026

Same author

Valve-Sparing Versus Composite Graft Aortic Root Replacement in Acute Type A Aortic Dissection with Standardized Hemiarch Repair: A Propensity Score Matching Analysis.

Journal of cardiovascular development and disease·2026

Same author

Prediction Scores Identifying Patients at High Risk of Endocarditis in Enterococcal Bacteremia.

Open forum infectious diseases·2026

A PASCAL device for mitral regurgitation dislocated, requiring explantation and valve replacement. Histopathological analysis of the device and leaflets followed this rare complication.

Area of Science:

Cardiovascular Medicine
Interventional Cardiology
Medical Device Technology

Background:

Severe degenerative mitral regurgitation is a significant clinical challenge.
Transcatheter mitral valve repair offers a less invasive treatment option.
The PASCAL device is utilized for mitral valve repair procedures.

Observation:

A 78-year-old female underwent PASCAL device implantation for severe mitral regurgitation.
Intraprocedural echocardiography identified device dislocation and persistent severe regurgitation.
A second device implantation was not feasible.

Findings:

The dislocated PASCAL device was successfully explanted after 8 days.
The patient subsequently underwent mitral valve replacement with a biological prosthesis.

Keywords:

Mitral regurgitation PASCAL device Transcatheter therapy

More Related Videos

Surgical Ablation Assay for Studying Eye Regeneration in Planarians

Surgical Ablation Assay for Studying Eye Regeneration in Planarians

Published on: April 14, 2017

Soft Lithographic Procedure for Producing Plastic Microfluidic Devices with View-ports Transparent to Visible and Infrared Light

Soft Lithographic Procedure for Producing Plastic Microfluidic Devices with View-ports Transparent to Visible and Infrared Light

Published on: August 17, 2017

Related Experiment Videos

Last Updated: Oct 13, 2025

Author Spotlight: Innovative Methodology for Implanting and Securing Neural Probes in the Rodent Spinal Cord

Author Spotlight: Innovative Methodology for Implanting and Securing Neural Probes in the Rodent Spinal Cord

Published on: July 12, 2024

Surgical Ablation Assay for Studying Eye Regeneration in Planarians

Surgical Ablation Assay for Studying Eye Regeneration in Planarians

Published on: April 14, 2017

Soft Lithographic Procedure for Producing Plastic Microfluidic Devices with View-ports Transparent to Visible and Infrared Light

Soft Lithographic Procedure for Producing Plastic Microfluidic Devices with View-ports Transparent to Visible and Infrared Light

Published on: August 17, 2017

Histopathological examination was performed on the explanted device and native valve tissue.

Implications:

Device dislocation is a potential complication of transcatheter mitral valve repair.
Explantation and valve replacement may be necessary in cases of device failure.
Histopathological analysis can provide insights into device-tissue interactions and failure mechanisms.