Related Experiment Videos
A cDNA encoding the precursor of the rat neuropeptide, neurokinin B
T I Bonner1, H U Affolter, A C Young
1Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.
Brain Research
|September 1, 1987
Abstract:
We have isolated a cDNA clone from a rat cerebral cortex library which encodes the 116 amino acid precursor of the neuropeptide, neurokinin B. The precursor has 68% amino acid homology to the bovine precursor and encodes a single peptide of the tachykinin family. Except for possible small variations at both ends of the message, there appears to be only a single species of neurokinin B mRNA in rat cerebral cortex. In situ hybridization histochemistry indicates that the message is widely distributed in the rat brain in a pattern distinct from that of substance P message.