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Three-dimensional cell-laden collagen scaffolds: From biochemistry to bone bioengineering
Lucas Fabricio Bahia Nogueira1,2, Bianca C Maniglia1, Rene Buchet3
1Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo (FFCLRP-USP), São Paulo, Brazil.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|November 18, 2021
Summary
This review explores bone as an organ and material, focusing on its complex matrix. It highlights how understanding bone
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Cell Biology
Background:
- Bones function as structural organs and complex hybrid organic/inorganic materials.
- Bone's matrix comprises collagen, noncollagenous proteins, and minerals, regulated by specialized cells.
- Cell-matrix interactions are vital for bone mechanics, healing, and response to injury.
Purpose of the Study:
- To bridge the gap between physical and biological properties for advanced bone tissue engineering scaffolds.
- To review bone tissue organization and its inspiration for 3D cell-laden collagenous scaffolds.
- To explore the role of noncollagenous macromolecules in matrix organization and cell mineralization.
Main Methods:
- Review of bone tissue structure and composition.
- Analysis of materials research inspired by bone's hierarchical organization.
- Examination of 3D cell-laden collagenous scaffolds for bone regeneration.
Main Results:
- Bone's unique organic/inorganic matrix organization inspires scaffold design.
- 3D cell-laden collagenous scaffolds aim to mimic bone's mechanical and biological properties.
- Noncollagenous macromolecules influence matrix structure and cellular mineralization.
Conclusions:
- Understanding extracellular matrix modulation of cell activity is key for scaffold performance.
- Improved scaffold design enhances bone regeneration, repair, and in vitro bone studies.
- This knowledge aids in unraveling bone's physiological and pathological processes.
