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Autosomal recessive and dominant forms of polycystic kidney disease are not allelic
B Wirth1, K Zerres, M Fischbach
1Institut für Humangenetik der Universität, Bonn, Federal Republic of Germany.
Human Genetics
|November 1, 1987
Abstract:
Linkage analysis has been carried out in 11 kindreds with autosomal recessive polycystic kidney disease (ARPKD) using the genetic marker 3'HVR, closely linked (theta = 0.05) to the gene of the autosomal dominant type. Close linkage (theta less than or equal to 0.20) between the locus of the marker and that of ARPKD can be excluded. These data strongly suggest that the loci for the autosomal recessive and dominant forms of polycystic kidney disease are not allelic.