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Antioxidant interventions in autism spectrum disorders: A meta-analysis
Yiying Liu1, Zimeng Yang1, Yang Du2
1Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, China.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|November 18, 2021
Summary
Antioxidant supplements show potential in managing some autism spectrum disorder (ASD) symptoms, particularly irritability and communication issues. Further research is needed to confirm their effectiveness in treating autism.
Area of Science:
- Neuroscience
- Clinical Psychology
- Pharmacology
Background:
- Autism spectrum disorder (ASD) is potentially linked to oxidative stress.
- Antioxidants are frequently used in managing ASD symptoms, but their efficacy is debated.
Purpose of the Study:
- To evaluate the effectiveness of antioxidant interventions on ASD symptoms through a meta-analysis.
- To synthesize evidence from placebo-controlled, double-blind, randomized clinical trials.
Main Methods:
- Searched PubMed and Web of Science databases for relevant studies.
- Included 13 double-blind randomized clinical trials with 570 participants (293 intervention, 277 placebo).
- Utilized Aberrant Behavior Checklist (ABC), Repetitive Behavior Scale-Revised (RBS), and other scales to assess symptom outcomes.
Main Results:
- Antioxidants, including N-acetylcysteine (NAC), improved irritability (ABC) and communication disturbances (DBC) compared to placebo.
- A positive trend was observed for stereotypic behaviors (ABC) and hyperactivity symptoms with NAC treatment.
- Effect sizes were small, with low statistical heterogeneity and publication bias.
Conclusions:
- Antioxidant intervention shows promise for managing specific ASD symptoms.
- Further research is warranted to explore the therapeutic potential of antioxidants in autism treatment.
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