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COVID-19 Vaccination Rates in a Global HIV Cohort

Evelynne S Fulda1, Kathleen V Fitch1, Edgar T Overton2

  • 1Metabolism Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.

The Journal of Infectious Diseases
|November 18, 2021
PubMed

Insights

COVID-19 vaccination rates were 55% among people with HIV (PWH) in the REPRIEVE trial by July 2021. Vaccination varied by region, with factors like income and age influencing uptake in this vulnerable population.

Area of Science:

  • Infectious Diseases
  • Public Health
  • HIV Medicine

Background:

  • People with HIV (PWH) are vulnerable to severe COVID-19 outcomes.
  • Limited data exist on coronavirus disease 2019 (COVID-19) vaccination rates within the PWH population.
  • Understanding vaccination patterns is crucial for targeted public health interventions.

Purpose of the Study:

  • To assess COVID-19 vaccination rates among PWH participating in the REPRIEVE trial.
  • To compare these rates with global and regional vaccination data.
  • To identify factors associated with vaccination uptake in PWH.

Main Methods:

  • Analysis of COVID-19 vaccination status in 6952 PWH from the REPRIEVE study.
  • Comparison of vaccination rates against region- and country-specific data up to July 2021.
  • Multivariable analysis to identify factors associated with vaccination.

Main Results:

  • The overall COVID-19 vaccination probability was 55% among REPRIEVE participants by end of July 2021.
  • Vaccination rates showed substantial variation across Global Burden of Disease (GBD) superregions.
  • Factors associated with higher vaccination rates included residing in high-income regions, older age, white race, male sex, higher BMI, and greater cardiovascular risk.

Conclusions:

  • COVID-19 vaccination uptake among PWH in the REPRIEVE trial was 55% by mid-2021, with significant regional disparities.
  • Socioeconomic and demographic factors, including income, age, race, sex, BMI, and cardiovascular risk, were associated with vaccination status.
  • Further research and targeted strategies are needed to improve equitable COVID-19 vaccine access and uptake in PWH globally.

Keywords:
COVID-19Global Burden of Disease regionhuman immunodeficiency virusvaccination

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