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Relationship between Serum Elabela Level and Hypertensıve Nephropathy
Yusuf Dogan1, Erhan Onalan1, Cundullah Cavli1
1Department of Internal Medicine, Firat University, Medical School, Elazig, Turkey.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|November 19, 2021
Summary
Serum Elabela levels are lower in patients with hypertension, regardless of kidney damage (nephropathy). This finding suggests Elabela may not be specific to hypertensive nephropathy but could indicate other chronic conditions.
Area of Science:
- Biochemistry
- Nephrology
- Cardiology
Background:
- Hypertension is a major risk factor for cardiovascular and kidney diseases.
- Elabela, a novel peptide, has been investigated for its potential role in various physiological processes.
- Understanding biomarkers associated with hypertension and its complications is crucial for patient management.
Purpose of the Study:
- To investigate serum Elabela levels in hypertensive patients with and without nephropathy.
- To compare Elabela levels between hypertensive patients and healthy controls.
- To determine if Elabela levels differ based on the presence or absence of hypertensive nephropathy.
Main Methods:
- A cross-sectional descriptive study was conducted with 137 participants.
- Participants were divided into three groups: healthy controls (n=50), hypertensive patients without nephropathy (n=50), and hypertensive patients with nephropathy (n=37).
- Serum Elabela levels were measured and compared across the groups, alongside other biochemical parameters.
Main Results:
- No significant differences in age or gender were observed between the groups.
- Median serum Elabela levels were significantly different across the three groups (p<0.001).
- Elabela levels were notably lower in hypertensive patients compared to healthy controls, irrespective of nephropathy status.
Conclusions:
- Plasma Elabela levels are reduced in hypertension, independent of nephropathy.
- The observed decrease in Elabela is not specific to hypertensive nephropathy.
- Further research is needed to explore the association of decreased Elabela with other chronic diseases in hypertensive individuals.
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