Related Experiment Video
Updated: Oct 13, 2025
09:16
Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
Published on: September 1, 2019
7.7K
Circular RNAs in acute myeloid leukemia
Vijendra Singh1, Mohammed Hafiz Uddin2, Jeffrey A Zonder1
1Department of Oncology, Karmanos Cancer Institute/Wayne State University, 4100 John R, HWCRC 740.2, Detroit, MI, 48201, USA.
Molecular Cancer
|November 19, 2021
Summary
Circular RNAs (circRNAs) show promise in understanding acute myeloid leukemia (AML) biology and treatment resistance. This review explores circRNAs as potential biomarkers for diagnosing, treating, and predicting outcomes in AML patients.
Area of Science:
- Hematology
- Molecular Biology
- Oncology
Background:
- Acute myeloid leukemia (AML) remains a challenge, with most patients relapsing despite targeted therapies.
- Current diagnostic methods for AML lack comprehensive predictive power for treatment resistance.
- There is a critical need for novel biomarkers in AML diagnosis, therapy, and prognosis.
Purpose of the Study:
- To review the emerging role of circular RNAs (circRNAs) in acute myeloid leukemia (AML).
- To explore the potential of circRNAs in understanding AML biology and therapeutic resistance.
- To identify circRNAs as potential diagnostic, therapeutic, and prognostic biomarkers for AML management.
Main Methods:
- Literature review focusing on recent studies of circRNAs in AML.
- Analysis of existing research on circRNA involvement in AML pathogenesis and treatment response.
- Synthesis of current knowledge regarding circRNAs as biomarkers.
Main Results:
- Circular RNAs are increasingly recognized for their involvement in complex biological processes within AML.
- Evidence suggests circRNAs play a role in both the development and progression of AML.
- circRNAs demonstrate potential as indicators of resistance to current AML therapies.
Conclusions:
- Circular RNAs represent a promising frontier in AML research.
- Further investigation into circRNAs could lead to improved diagnostic tools and therapeutic strategies for AML.
- Harnessing the potential of circRNAs may help overcome treatment resistance and improve patient outcomes in AML.
Related Concept Videos
02:23Abnormal Proliferation
4.7K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.6K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.6K
02:53Ribosomal RNA Synthesis
13.7K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
13.7K
01:15Differentiation of Common Myeloid Progenitor Cells
3.4K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.4K
01:51Mechanisms of Retrovirus-induced Cancers
5.4K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.4K