Dispersive magnetic solid phase microextraction on microfluidic systems for extraction and determination of parabens

Area of Science:

• Analytical Chemistry
• Materials Science

Background:

• Parabens are widely used preservatives with potential health concerns.
• Efficient extraction methods are crucial for accurate paraben detection in diverse matrices.

Purpose of the Study:

• To develop and optimize a microfluidic system for magnetic solid phase extraction (MSPE) of parabens.
• To synthesize and characterize polyaniline-coated magnetite nanoparticles for enhanced paraben extraction.

Main Methods:

• Synthesis and characterization of polyaniline-coated magnetite nanoparticles.
• Fabrication of a spiral microfluidic chip using laser-cutting.
• Optimization of parameters for nanoparticle dispersion and MSPE.
• Analysis of parabens using optimized microfluidic system.

Main Results:

• Successfully synthesized and characterized magnetic nanoparticles with suitable properties for extraction.
• Optimized microfluidic system demonstrated efficient dispersion and stability of nanoparticles.
• Achieved high linearity (R² > 0.992) and low variability (RSD < 7.2%) for paraben quantification.
• Demonstrated favorable accuracy and precision for paraben extraction from real-world samples (fruit juice, sunscreen, urine).

Conclusions:

• The developed microfluidic MSPE system is effective for sensitive and selective determination of parabens.
• Polyaniline-coated magnetite nanoparticles provide efficient extraction and magnetic separation.
• The method shows promise for routine analysis of parabens in complex matrices.