Dose-response relationship between urinary PAH metabolites and blood viscosity among coke oven workers: a
Min Wu1, Chengjuan Liu1, Huimin Wang1
1School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China.
Objectives:
Polycyclic aromatic hydrocarbons (PAHs) have been proven to be a risk factor for cardiovascular disease in coke oven workers, and increased plasma viscosity is a signal for higher risk of catching up cardiovascular disease. We want to explore whether the plasma viscosity is affected by the concentration of PAHs.
Design:
Our study is a cross-sectional dose-response study.
Setting:
Participants in this study came from a coke plant in Taiyuan, Shanxi.
Participants:
We used data of 693 coke oven workers in Taiyuan.
Primary And Secondary Outcome Measures:
We assumed that plasma viscosity would increase as the concentration of PAHs metabolites in urine increases. We found that 2-hydroxyfluorene (OHFLU2) and plasma viscosity have a stable linear relationship in different statistical methods.
Results:
We found that plasma viscosity increased by 1.14 (mPa.s,30/s) for each ng/mL of 2-OHFLU urinary (correlation coefficient range: 0.54-1.74, p<0.05).
Conclusions:
The results of this study could provide evidence for coke oven workers to prevent cardiovascular disease by checking whether plasma viscosity is elevated.
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