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Updated: Oct 12, 2025

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Intractable Cough Associated With Renal Cell Carcinoma
Arminder Singh1, Stephanie Everest2, Lam Nguyen2
1Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
This case study highlights a rare instance of intractable cough as a paraneoplastic syndrome associated with renal cell carcinoma (RCC). Early diagnosis and treatment with immunotherapy were crucial for this elderly patient.
Area of Science:
- Oncology
- Nephrology
- Pulmonology
Background:
- Renal cell carcinoma (RCC) typically presents with abdominal pain, hematuria, and flank pain.
- Paraneoplastic syndromes, while known complications of malignancy, are rarely associated with RCC.
Observation:
- An 86-year-old female presented with a persistent dry cough lasting two months.
- Abdominal CT revealed a large left renal mass with metastatic disease to regional lymph nodes.
Findings:
- Biopsy confirmed the renal mass as renal cell carcinoma.
- The patient's intractable cough was suspected to be a paraneoplastic manifestation of RCC.
Implications:
- This case underscores the importance of considering rare paraneoplastic syndromes in the differential diagnosis of unexplained symptoms.
- Highlights the potential for immunotherapy in managing advanced renal cell carcinoma, even in elderly, nonsurgical candidates.
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