Jove
Visualize
Contact Us

Related Concept Videos

Generator Voltage Control01:21

Generator Voltage Control

265
Generator voltage control is crucial for maintaining the stable operation of synchronous generators and wind turbines. In older models, a DC generator driven by the rotor delivers DC power to the rotor's field winding, and the power is transferred through slip rings and brushes. In the latest models, static or brushless exciters are used. Static exciters rectify AC power from the generator terminals and then transfer the DC power directly to the rotor. Brushless exciters, on the other hand,...
265
DC Generator01:19

DC Generator

1.2K
An alternator converts mechanical energy into electrical energy that varies sinusoidally, resulting in AC current. Meanwhile, a DC generator converts mechanical energy into electrical energy, which are DC pulses with the same polarity. The construction of a DC generator is similar to that of an alternator, except that the pair of slip rings is replaced by a single split ring, also called a commutator. The commutator functions like a periodic rotary switch; it changes the contacts with the...
1.2K
Machines01:19

Machines

373
Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. One example of a machine is the cutting plier, which is used to cut wires by applying forces to its handles. When equal and opposite forces are exerted on the handles of the cutting plier, they cause the cutting edges to come together and apply equal and opposite reaction forces on the wire, which are greater than the applied forces.
A free-body diagram of the...
373
Clamper Circuit01:14

Clamper Circuit

639
A clamper circuit, also known as a DC restorer, represents a specialized variant of the rectifier circuit, notable for its method of taking the output across the diode rather than the capacitor. This configuration lends to several distinctive applications, particularly in handling square wave inputs.
Within this circuit, the diode's orientation prompts the capacitor to charge up to the level of the most negative peak of the input signal. Upon reaching this state, the diode ceases to...
639
Electric Generator: Alternator01:25

Electric Generator: Alternator

2.7K
Electric generators induce an emf by rotating a coil in a magnetic field. A simple alternator is an AC generator that creates electrical energy that varies sinusoidally with time. A simple alternator consists of a conducting loop that is placed inside a uniform magnetic field. The loop is connected to split rings connected to the external circuit with the help of brushes.
The magnetic flux passing through the coil varies sinusoidally as the loop rotates inside the magnetic field. This...
2.7K
Steel Manufacturing01:26

Steel Manufacturing

885
Steel manufacturing is a multi-stage process that begins by smelting iron ore into cast iron in a blast furnace. This initial stage involves layering iron ore with coke, a type of fuel, and crushed limestone within the furnace. The coke is ignited with a high volume of air, leading to the creation of carbon monoxide, which acts to reduce the iron ore to pure iron.
During this smelting process, limestone plays a crucial role by forming slag. Slag captures impurities within the molten iron, such...
885

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>TLR7</i> mutations leading to enhanced TLR7 signaling in humans.

Journal of human immunity·2026
Same author

2'-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity.

Nature immunology·2026
Same author

UNCovering new causes of monogenic systemic lupus erythematosus.

Immunology and cell biology·2024
Same author

Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation.

Life science alliance·2023
Same author

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection.

Nature communications·2023
Same author

Genistein Targets STING-Driven Antiviral Responses.

mBio·2022
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 12, 2025

Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

6.8K

Powering on cGAMP mini factories.

Michael P Gantier1,2

  • 1Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Vic., Australia.

EMBO Reports
|November 19, 2021
PubMed
Summary

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA to trigger innate immunity. A new study reveals cGAS activation relies on forming condensates with G3BP1, uncovering a novel DNA sensing mechanism.

More Related Videos

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.4K
Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices
07:15

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Published on: April 14, 2021

3.9K

Related Experiment Videos

Last Updated: Oct 12, 2025

Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

6.8K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.4K
Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices
07:15

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Published on: April 14, 2021

3.9K

Area of Science:

  • Innate immunity
  • Molecular biology
  • Cellular signaling

Background:

  • Cyclic GMP-AMP synthase (cGAS) is a key sensor in the innate immune system.
  • cGAS detects pathogenic DNA and also monitors cellular health by sensing aberrant nuclear and mitochondrial DNA in the cytoplasm.
  • Understanding the regulation of cGAS is crucial due to its central role in immune surveillance.

Purpose of the Study:

  • To elucidate novel regulatory mechanisms controlling cGAS activation.
  • To investigate the role of protein condensates in cGAS-mediated DNA sensing.

Main Methods:

  • The study utilized biochemical assays and cellular imaging techniques.
  • Investigated the interaction between cGAS and GTPase-activating protein-(SH3 domain)-binding protein 1 (G3BP1).
  • Focused on the formation of primary condensates involving cGAS and G3BP1.

Main Results:

  • A novel mechanism for activating DNA sensing by cGAS was identified.
  • The formation of primary condensates between cGAS and G3BP1 is essential for switching on DNA sensing.
  • This condensate formation represents a new regulatory step in cGAS pathway activation.

Conclusions:

  • The findings reveal a previously unknown mechanism for initiating cGAS-dependent immune responses.
  • Condensate formation involving cGAS and G3BP1 is critical for initiating DNA sensing.
  • This discovery deepens our understanding of innate immune regulation and cellular surveillance.