The correlation between lipoprotein associated phospholipase A₂ and central overweight status

Area of Science:

• Cardiovascular Research
• Metabolic Health
• Biomarker Discovery

Background:

• Overweight status increases risks for diabetes mellitus, hypertension, and cardiovascular disease.
• Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent predictor of cardiovascular disease risk.

Purpose of the Study:

• To investigate the association between Lp-PLA2 levels and overweight status in Chinese adults.
• To explore Lp-PLA2 distribution across different overweight classifications and its correlation with comorbidities.

Main Methods:

• Cross-sectional study of 3760 Chinese adults (aged 18-50) from 2018-2020.
• Evaluation of Lp-PLA2 levels in relation to overweight status, adjusting for influencing factors.
• Analysis of Lp-PLA2 levels across sex, weight classifications, and presence of comorbidities (diabetes, hypertension, metabolic syndrome).

Main Results:

• Lp-PLA2 levels were significantly higher in males than females.
• Central overweight status was associated with higher Lp-PLA2 compared to normal or peripheral overweight status.
• Elevated Lp-PLA2 was observed in individuals with diabetes mellitus, hypertension, and metabolic syndrome.

Conclusions:

• Lp-PLA2 is associated with sex, central overweight status, diabetes, hypertension, and metabolic syndrome in adults under 50.
• Age-adjusted and LDL-adjusted Lp-PLA2 levels were notably higher in the diabetes positive, hypertension negative subgroup compared to other combinations.
• Lp-PLA2 may serve as a valuable biomarker for cardiovascular risk stratification in overweight Chinese adults.