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[From treating in the dark towards eliminating hepatitis C].
Peer Brehm Christensen1, Jacob Søholm, Anne Øvrehus
1peer.christensen@dadlnet.dk.
Ugeskrift for Laeger
|November 19, 2021
Summary
Hepatitis C (HCV) treatment evolved from interferon to direct-acting antivirals, achieving a cure for all patients. Elimination requires outreach, point-of-care testing, and treatment, with Denmark aiming for WHO goals by 2030.
Area of Science:
- Hepatology
- Virology
- Public Health
Background:
- Hepatitis C virus (HCV) infection historically lacked effective treatments.
- Early therapies like interferon showed limited cure rates (10-20%).
- Combination therapy with interferon and ribavirin improved outcomes but did not ensure a complete cure.
Purpose of the Study:
- To review the evolution of hepatitis C treatment.
- To advocate for strategies to eliminate HCV globally.
- To assess the feasibility of Denmark meeting WHO elimination targets.
Main Methods:
- Literature review of HCV treatment modalities.
- Analysis of treatment efficacy and cure rates.
- Discussion of public health strategies for HCV elimination.
Main Results:
- Interferon monotherapy achieved low cure rates.
- Adding ribavirin and extending therapy duration increased cure rates to 40-60%.
- Direct-acting antivirals (DAAs) have led to a definitive cure for HCV.
Conclusions:
- Direct-acting antivirals represent a breakthrough, offering a cure for all HCV patients.
- Achieving HCV elimination necessitates proactive strategies, including outreach and point-of-care testing and treatment.
- Denmark is positioned to meet the World Health Organization's (WHO) HCV elimination goals before 2030.
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