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When it's time for the sex talk, words matter
Austin T Robinson1, Megan M Wenner2, Kanokwan Bunsawat3
1Neurovascular Physiology Laboratory, School of Kinesiology, Auburn University, Auburn, Alabama.
American Journal of Physiology. Heart and Circulatory Physiology
|November 19, 2021
Summary
Biomedical research must move beyond the "default male" by accurately including sex as a biological variable. This ensures health equity and precise scientific understanding for all participants.
Area of Science:
- Physiology
- Biomedical Research
- Health Equity
Background:
- Historical underrepresentation of females in biomedical studies is increasingly criticized.
- The 'default human' in research has traditionally been the young, healthy male.
- Current calls for papers emphasize addressing sex as a biological variable.
Discussion:
- Discusses appropriate terminology (man/woman vs. male/female) for human research participants.
- Highlights the importance of sex as a biological variable, akin to gender identity's impact on health.
- Emphasizes the need for precise language when referring to research volunteers.
Key Insights:
- Consensus reached on the importance of terminology and sex as a biological variable.
- Recommends appropriate inclusion of biological sex in all research phases (in vitro, preclinical, human).
- Addresses the critical need for accurate representation beyond the 'default male' paradigm.
Outlook:
- Promotes greater inclusivity and accuracy in biomedical research design and reporting.
- Encourages a shift towards sex-inclusive research for improved health outcomes.
- Advocates for standardized terminology to enhance scientific rigor and clarity.