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Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical
E V Inzhevatkin1,2, A V Baron3, M B Volkova4
1International Scientific Center of Extremal Organism State Research, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia. inscience@mail.ru.
Abstract:
Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.
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