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Linkage of TNF genes to the HLA-B locus
1Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
Nucleic Acids Research
|November 11, 1987
Abstract:
Pulsed field gel electrophoresis was used to determine the location of the tumour necrosis factor (TNF) alpha and beta genes. They were shown to be linked to the HLA-B locus; analogous to their location in mouse, between the complement (class III) region and H-2D. However, the distance between the TNF genes and the class I region was much greater in man, namely about 260 kb, compared to 70 kb in the mouse. This finding may have implications for some HLA associated diseases.