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Microfluidics in Assessing Platelet Function
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Dynamics of fibrinogen in acute phases of trauma

Mineji Hayakawa1

  • 1Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, Sapporo, 060-8648, Japan. mineji@dream.com.

Journal of Intensive Care
|November 20, 2021
PubMed

Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropriate firmness. In severe trauma patients, plasma fibrinogen concentrations decrease earlier and more frequently than other coagulation factors, predicting massive bleeding and death. We review the mechanisms of plasma fibrinogen concentration decrease, which include coagulation activation-induced consumption, hyper-fibrino(geno)lysis-induced degradation, and dilution by infusion/transfusion. Understanding the mechanisms of plasma fibrinogen concentration decrease in severe trauma patients is crucial.

Keywords:
CoagulopathyDisseminated intravascular coagulationFibrinogenFibrinolysisMassive bleedingTransfusionTrauma

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