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Published on: May 14, 2013
Impact of anemia on in-stent restenosis after percutaneous coronary intervention
Huilin Hu1, Shijun Wang1, Guanmin Tang1
1Department of Cardiology, Affiliated Hospital of Jiaxing University, No.1882 Zhonghuan South Road, Jiaxing, Zhejiang, China.
Insights
Anemia significantly increases the risk of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Lower hemoglobin levels are linked to a higher likelihood of developing ISR post-procedure.
Area of Science:
- Cardiology
- Interventional Cardiology
- Hematology
Background:
- Anemia is a known risk factor for adverse events following percutaneous coronary intervention (PCI).
- Limited data exists on the association between anemia and in-stent restenosis (ISR) after PCI.
Purpose of the Study:
- To investigate the relationship between anemia and the occurrence of ISR in patients who have undergone PCI.
- To identify predictors of ISR, including anemia, in the post-PCI setting.
Main Methods:
- A study cohort of 538 patients undergoing PCI between January 2017 and September 2019 was analyzed.
- Follow-up angiography was performed 9-12 months post-PCI.
- Propensity score matching was used to compare baseline characteristics and determine independent predictors of ISR.
Main Results:
- The incidence of anemia was substantially higher in patients with ISR (53.5%) compared to those without ISR (19.0%).
- Anemia was independently associated with ISR (OR, 4.283; P < 0.001) after propensity score matching.
- Other significant predictors of ISR included diabetes mellitus, chronic kidney disease, multiple stenting, bifurcation lesions, calcification, LDL-c levels, and stent diameter.
Conclusions:
- Anemia is a significant risk factor for developing in-stent restenosis after percutaneous coronary intervention.
- Patients with lower hemoglobin levels demonstrate an elevated risk of ISR post-PCI.
Background:
Anemia is a common risk factor for post-percutaneous coronary intervention (PCI) adverse events; however, data on its association with in-stent restenosis (ISR) is limited.
Methods:
538 patients who underwent PCI between January 2017 and September 2019 and follow-up angiography 9-12 months after the initial PCI were enrolled in this study. Baseline clinical and procedural characteristics were compared between the ISR and non-ISR groups, and independent predictors of ISR were determined using propensity score matching.
Results:
The incidence of anemia was 53.5% in patients with ISR and 19.0% in those without ISR. Univariable logistic regression analyses showed that anemia (OR, 4.283; 95% CI, 1.949-9.410; P < 0.001), diabetes mellitus (OR, 2.588; 95% CI, 1.176-5.696; P = 0.018), chronic kidney disease (OR, 3.058; 95% CI, 1.289-7.252; P = 0.011), multiple stenting (OR, 2.592; 95% CI, 1.205-5.573; P = 0.015), bifurcation lesion (OR, 2.669; 95% CI, 1.236-5.763; P = 0.012), and calcification (OR, 3.529; 95% CI, 1.131-11.014; P = 0.030) were closely associated with ISR. Low-density lipoprotein cholesterol (LDL-c) levels and stent diameter were also significantly linked to ISR, as was anemia (P = 0.009) after propensity score matching.
Conclusion:
Anemia is closely associated with post-PCI ISR, and patients with lower hemoglobin levels are at a higher risk of ISR.
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