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Updated: Oct 12, 2025

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Shifting acute stroke management to the prehospital setting
Martin Ebinger1,2, Heinrich J Audebert1,3
1Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin.
Mobile stroke units significantly reduce treatment times for acute ischemic stroke patients, especially in urban areas. Further research should optimize dispatch and endovascular therapy referrals for these mobile units.
Area of Science:
- Neurology
- Emergency Medicine
- Public Health
Background:
- Early treatment is critical for improving outcomes in acute ischemic stroke.
- Optimizing prehospital care is essential for reducing treatment delays.
Purpose of the Study:
- To review recent literature on prehospital stroke care strategies.
- To compare mothership vs. drip-and-ship models and mobile stroke units.
Main Methods:
- Literature review of prehospital stroke care strategies.
- Analysis of treatment times associated with different prehospital models.
Main Results:
- Mobile stroke units demonstrate the shortest onset-to-treatment times, particularly in urban environments.
- Comparison of mothership and drip-and-ship models in prehospital stroke care.
Conclusions:
- Mobile stroke units offer a promising approach to reduce treatment delays for acute ischemic stroke.
- Future research should focus on enhancing mobile stroke unit efficiency through improved dispatch and endovascular therapy referral processes.
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