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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
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Emerging technologies and infection models in cellular microbiology.

Ana Teresa López-Jiménez1, Serge Mostowy2

  • 1Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

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Cellular microbiology explores how microbes infect cells. Emerging technologies like AI and organoids offer new ways to study host-pathogen interactions and develop anti-infective strategies.

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Area of Science:

  • Cellular microbiology
  • Host-pathogen interactions
  • Infectious disease research

Background:

  • Cellular microbiology investigates the co-evolution of microbes and hosts.
  • Focuses on intracellular pathogens and their manipulation of host cell processes.
  • Understanding these interactions is crucial for combating infectious diseases.

Purpose of the Study:

  • To review recent advancements in cellular microbiology.
  • Highlight emerging technologies and infection models.
  • Discuss their impact on studying host-pathogen dynamics.

Main Methods:

  • Advanced microscopy techniques for host-pathogen interface visualization.
  • Robotics and artificial intelligence for high-throughput screening.
  • Biochemical mapping and dual RNA-sequencing.
  • In vitro (organoids, chips) and in vivo (animal) models.

Main Results:

  • New technologies provide unprecedented detail of intracellular infection.
  • Robotics, AI, and sequencing enhance screening and analysis.
  • Organoids and animal models allow study of biophysical and in vivo infection aspects.

Conclusions:

  • Advancements in cellular microbiology deepen our understanding of the infected cell.
  • These insights hold significant promise for developing novel anti-infective strategies.
  • Translational applications in human health are a key future direction.