Related Experiment Video

Updated: Oct 12, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

86.7K

Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes

Yea-Seul Han1, Sung-Ha Kim1, Tae-Jung Sung2

  • 1Department of Pediatrics, Hallym University Medical Center, Kangnam Sacred Heart Hospital, Seoul, Korea.

Scientific Reports
|November 20, 2021
PubMed

Insights

The Neonatal Research Network (NRN) criteria for bronchopulmonary dysplasia (BPD) better predict neurodevelopmental impairment in preterm infants than NIH criteria. Grade 3 BPD under NRN criteria shows high accuracy in identifying infants at risk for poor outcomes.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Developmental Pediatrics

Background:

  • Bronchopulmonary dysplasia (BPD) significantly impacts neonatal care, particularly for low-birth-weight infants.
  • Understanding long-term pulmonary and neurologic outcomes is crucial for managing BPD.
  • Existing diagnostic criteria for BPD, such as NIH (2001) and NRN (2019), may vary in their predictive power for long-term sequelae.

Purpose of the Study:

  • To compare the predictive accuracy of the NIH and NRN criteria for diagnosing bronchopulmonary dysplasia (BPD).
  • To determine which BPD definition best predicts long-term pulmonary and neurodevelopmental outcomes in preterm infants.
  • To evaluate the association between BPD severity and neurodevelopmental impairment (NDI).

Main Methods:

  • Utilized Korean nationwide data from preterm infants born between 24 and 32 weeks gestation (2013-2015).
  • Analyzed long-term outcomes, including respiratory disorder readmissions and neurodevelopmental impairment at 18-24 months.
  • Compared the performance of NIH and NRN diagnostic criteria, including severity grading, in predicting these outcomes.

Main Results:

  • The Neonatal Research Network (NRN) criteria demonstrated a stronger association with poor 2-year developmental outcomes compared to NIH criteria.
  • Grade 3 BPD by NRN criteria showed high specificity (96%) and accuracy (83%) for predicting respiratory disorder readmissions.
  • For predicting neurodevelopmental impairment (NDI), NRN grade 3 BPD exhibited superior specificity (98%) and accuracy (78%), while NIH severe BPD had higher sensitivity (60%).

Conclusions:

  • The NRN BPD definition appears more effective in identifying preterm infants at high risk for neurodevelopmental impairment.
  • The NRN criteria may offer a more robust tool for predicting adverse long-term outcomes in bronchopulmonary dysplasia.
  • This study supports the use of NRN criteria for better risk stratification and management of BPD in neonates.

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.5K
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

24.7K

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
423
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
192
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
917
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.0K
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
43.1K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.0K