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Serotonin and systemic sclerosis. An emerging player in pathogenesis.

Ioannis Sagonas1, Dimitrios Daoussis2

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Serotonin plays a key role in systemic sclerosis (SSc) by contributing to fibrosis and vasculopathy. Further research into serotonin pathways may reveal new therapeutic targets for SSc treatment.

Keywords:
FibrosisPulmonary arterial hypertensionRaynaud'sSclerodermaSerotoninSystemic sclerosisVasculopathy

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Area of Science:

  • Immunology
  • Pathophysiology
  • Pharmacology

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease marked by fibrosis and vasculopathy.
  • Serotonin is implicated in SSc pathogenesis, influencing fibrotic processes and vascular issues like Raynaud's phenomenon and pulmonary arterial hypertension.

Purpose of the Study:

  • To review current knowledge on serotonin's role in SSc.
  • To provide a rationale for investigating serotonin as a therapeutic target in SSc.

Main Methods:

  • Literature search of Medline and Cochrane databases.
  • Keywords included systemic sclerosis, scleroderma, Raynaud's, pulmonary arterial hypertension, and serotonin.
  • Data search up to April 2021.

Main Results:

  • Serotonin regulates fibrosis and vasculopathy, driving fibrosis in skin and organs.
  • Experimental data show serotonin promotes platelet aggregation, vasoconstriction, and increased pulmonary vascular resistance.
  • Previous trials on serotonin inhibitors yielded mixed results, but recent advances offer new therapeutic insights.

Conclusions:

  • Serotonin is a potential mediator of fibrosis and vasculopathy in SSc.
  • Further investigation of serotonin's role in SSc is warranted.
  • Understanding serotonin pathways may lead to novel SSc therapeutics.