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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
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Enhancing bioaccessibility and bioavailability of carotenoids using emulsion-based delivery systems
Nuntarat Boonlao1, Uracha Rungsardthong Ruktanonchai2, Anil Kumar Anal1
1Department of Food, Agriculture and Bioresources, Asian Institute of Technology, P.O. Box 4, Klong Luang, Pathum Thani 12120, Thailand.
Colloids and Surfaces. B, Biointerfaces
|November 20, 2021
Summary
Carotenoids boost immunity but face stability and solubility issues. Emulsion-based delivery systems can improve their bioavailability for wider food and pharmaceutical applications.
Area of Science:
- Nutritional Science
- Food Chemistry
- Biochemistry
Background:
- Carotenoids are vital antioxidants and immune boosters, offering pro-vitamin A activity.
- Their lipophilic nature leads to poor solubility, chemical instability, and low bioavailability.
- Degradation occurs during food processing, storage, and digestion, limiting applications.
Purpose of the Study:
- To review challenges in carotenoid incorporation and delivery.
- To focus on stability and factors influencing carotenoid bioavailability.
- To explain emulsion-based delivery systems for enhanced carotenoid bioaccessibility and bioavailability.
Main Methods:
- Literature review on carotenoid properties and delivery systems.
- Analysis of factors affecting carotenoid stability and bioavailability.
- Examination of emulsion-based systems for carotenoid delivery.
Main Results:
- Carotenoids are susceptible to degradation from environmental factors.
- Poor solubility and instability limit their use in aqueous food systems.
- Emulsion-based systems show promise for improving carotenoid solubility, stability, and bioavailability.
Conclusions:
- Effective delivery systems are crucial for overcoming carotenoid limitations.
- Emulsion-based systems offer a viable strategy to enhance carotenoid efficacy.
- Delivery system design should align with specific applications and targets.
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