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Increased serum C1q/TNF-related protein 4 concentration in patients with acute coronary syndrome
Yunlang Dai1, Jing Zhou1, Lijuan Niu2
1Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Insights
The study found that CTRP4 levels are higher in patients with acute coronary syndrome (ACS), a type of coronary artery disease (CAD). ACS independently predicts CTRP4 concentration, suggesting CTRP4 may play a role in the inflammation linked to ACS.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Inflammation Research
Background:
- Coronary artery disease (CAD) is a significant health concern.
- C1q/TNF-related proteins (CTRPs) are implicated in CAD.
- The role of CTRP4 in CAD, particularly acute coronary syndrome (ACS), remains unexplored.
Purpose of the Study:
- To investigate the association between CTRP4 and CAD.
- To specifically examine the role of CTRP4 in acute coronary syndrome (ACS).
Main Methods:
- 138 patients were categorized into ACS, CAD, and control groups.
- Clinical data and CTRP4 concentrations were compared across groups.
- Weighted least-squares regression analysis identified independent predictors of CTRP4.
Main Results:
- ACS patients exhibited significantly higher CTRP4 concentrations compared to CAD and control groups.
- Elevated CTRP4 levels correlated with an increased presence of ACS.
- ACS was identified as the sole independent predictor of CTRP4 concentration, even after adjusting for high-sensitivity C-reactive protein.
Conclusions:
- CTRP4 is significantly associated with ACS.
- ACS is an independent predictive factor for CTRP4 concentration.
- CTRP4 may offer new insights into the relationship between inflammation and ACS.
Abstract:
Accumulated evidence have revealed profound associations between C1q/TNF-related proteins (CTRPs) and coronary artery disease (CAD); yet, the relationship of CTRP4 to CAD has not been investigated. We examined the role of CTRP4 in CAD, and especially in acute coronary syndrome (ACS).
Methods:
A total of 138 patients referred for coronary angiography were included in this study and were classified into 3 groups (ACS, CAD and control group). Comparisons regarding clinical data and CTRP4 concentration were performed among 3 groups. Weighted least-squares regression analysis was used to identify the independent predicting factors for CTRP4.
Results:
Compared with either CAD (median 7.19 vs. 9.43, P < 0.05) or control group (median 7.22 vs. 9.43, P < 0.01), ACS group showed higher CTRP4 concentration. In addition, trend χ2 test revealed the presence of ACS increased with increased CTRP4 concentration (P = 0.010). Finally, in the weighted least-squares regression analysis, ACS was the only independent variable influencing CTRP4 concentration (β- coefficient = 3.082, P = 0.004), even after adjusting for high-sensitivity C reactive protein (β- coefficient = 3.050, P = 0.007).
Conclusions:
CTRP4 was associated with ACS; moreover, ACS was the independent factor in predicting CTRP4 concentration. The potentially important implications of CTRP4 in ACS may offer a novel insight into understanding the link between inflammation and ACS.
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