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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

959
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Related Experiment Video

Updated: Oct 12, 2025

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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Multilayer Macula Vessel Density and Visual Field Progression in Glaucoma.

Alireza Kamalipour1, Sasan Moghimi1, Huiyuan Hou1

  • 1From the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.

American Journal of Ophthalmology
|November 21, 2021
PubMed
Summary
This summary is machine-generated.

Lower macular superficial vessel density (SVD) in glaucoma patients is linked to a higher chance of past visual field (VF) progression. Optical coherence tomography angiography may help identify glaucoma patients at risk of VF loss.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Early detection of glaucoma progression is crucial for timely intervention and vision preservation.
  • Macular vessel density, assessed via optical coherence tomography angiography (OCTA), is a potential biomarker for glaucoma.

Purpose of the Study:

  • To investigate the association between macular superficial vessel density (SVD) and deep vessel density (DVD) and past visual field (VF) progression in POAG patients.
  • To determine if OCTA can identify eyes at risk for glaucoma progression.

Main Methods:

  • A retrospective cohort study included 208 eyes from 147 POAG patients with at least five 24-2 VF tests over 3 years prior to OCTA imaging.
  • VF progression was assessed using event-based and trend-based methods.
  • Linear mixed-effects models evaluated the association of macular SVD and DVD with VF progression probability and rate.

Main Results:

  • 25% of eyes showed VF progression.
  • Lower baseline macular SVD was significantly associated with a higher likelihood of past VF progression (OR=1.28).
  • Lower macular SVD correlated with a faster rate of past mean deviation decline (coefficient = -0.03 dB/year).
  • Macular DVD showed no significant association with past VF progression.

Conclusions:

  • Reduced macular SVD, not DVD, is a predictor of past VF progression in POAG.
  • OCTA imaging holds promise for identifying glaucoma patients at risk of future vision loss.