Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

561
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
561
Translation01:31

Translation

16.3K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
16.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.3K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct and indirect regulation of fetal globin transcript by RNA-binding protein IGF2BP1.

Blood·2026
Same authorSame journal

Inhibition of MLLT1 Limits Growth of KMT2A::AFF1 Leukemias Without Killing Healthy Hematopoietic Stem Cells.

Experimental hematology·2026
Same author

The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia.

Blood·2026
Same author

Beyond neutropenia: Immunological evaluation of patients with Shwachman-Diamond syndrome.

British journal of haematology·2026
Same author

miR-93-mediated PTEN suppression and CNS-specific T cell exhaustion shape the leukemia niche in infant KMT2A::AFF1+ B-ALL.

Cell reports·2026
Same author

Liver stiffness in patients with Shwachman-Diamond syndrome.

JPGN reports·2026

Related Experiment Video

Updated: Oct 12, 2025

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

2.7K

Translational research for bone marrow failure patients.

Camille Malouf1, Stephen J Loughran2, Adam C Wilkinson3

  • 1Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.

Experimental Hematology
|November 21, 2021
PubMed
Summary
This summary is machine-generated.

Bone marrow failure syndromes are serious blood disorders. Research is advancing genetic understanding and gene therapies for inherited conditions like Fanconi anemia and Shwachman-Diamond syndrome.

More Related Videos

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

13.1K
Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.4K

Related Experiment Videos

Last Updated: Oct 12, 2025

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

2.7K
Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

13.1K
Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.4K

Area of Science:

  • Hematology
  • Genetics
  • Oncology

Background:

  • Bone marrow failure syndromes (BMFS) are a group of inherited and acquired hematological diseases.
  • These conditions lead to insufficient blood cell production, causing anemia, immune deficiency, coagulation problems, and cancer risk.
  • Notable inherited BMFS include Fanconi anemia and Shwachman-Diamond syndrome.

Purpose of the Study:

  • To review recent advancements in understanding the genetic landscape of inherited bone marrow failure syndromes.
  • To discuss the development of novel gene therapies for monitoring and treating BMFS.
  • To summarize key topics from the Winter 2021 International Society for Experimental Hematology New Investigator Webinar.

Main Methods:

  • Review of presentations from leading researchers in experimental hematology.
  • Synthesis of current knowledge on genetic characterization of BMFS.
  • Overview of emerging gene therapy strategies for hematological disorders.

Main Results:

  • Highlighting the genetic complexity of inherited BMFS.
  • Discussing the potential of gene therapy for improving patient outcomes.
  • Emphasizing the importance of continued research in experimental hematology.

Conclusions:

  • There is a growing need for comprehensive genetic characterization of BMFS.
  • Gene therapy offers promising avenues for treating these complex hematological diseases.
  • Further research is crucial for developing effective monitoring and curative strategies for BMFS patients.