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A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks
Published on: April 28, 2023
A turn-on NIR fluorescence sensor for gossypol based on Yb-based metal-organic framework
Wenwen Fan1, Yi Cheng1, Haili Zhao1
1Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education Functional Molecules Analysis and Biotransformation, Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, No. 2 North Cuihu Road, Kunming, 650091, PR China.
A new metal-organic framework (MOF), QBA-Yb, enables sensitive, turn-on near-infrared fluorescence detection of gossypol (Gsp). This method offers a rapid and reliable approach for detecting Gsp in food safety and medical applications.
Area of Science:
- Analytical Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Gossypol (Gsp) detection is crucial for food safety and medical applications.
- Existing analytical methods for Gsp face challenges in selectivity and sensitivity.
- Developing novel detection strategies is essential for accurate Gsp quantification.
Purpose of the Study:
- To develop a novel turn-on near-infrared (NIR) fluorescence detection strategy for gossypol (Gsp).
- To utilize a metal-organic framework (MOF), QBA-Yb, for enhanced Gsp sensing.
- To establish a sensitive and selective analytical method for Gsp determination.
Main Methods:
- Synthesis of QBA-Yb MOF using solvothermal methods.
- Investigating the interaction between Gsp and QBA-Yb MOF.
- Utilizing NIR fluorescence spectroscopy for Gsp detection with 467 nm excitation.
- Analyzing Gsp in real cottonseed samples.
Main Results:
- The QBA-Yb MOF exhibited a turn-on NIR fluorescence response to Gsp.
- The developed method demonstrated high sensitivity with a low detection limit (0.65 μg/mL).
- A wide linear range (5-160 μg/mL) and rapid response time (within 10 min) were achieved.
- The probe was successfully applied to detect Gsp in cottonseed samples.
Conclusions:
- The QBA-Yb MOF provides an effective platform for sensitive and selective Gsp detection.
- The turn-on NIR fluorescence strategy offers advantages for Gsp analysis in complex matrices.
- This method holds promise for practical applications in food safety and medical diagnostics.
