Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies

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Wissam H Faour1, Ali Choaib2, Elio Issa2

  • 1Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon. wissam.faour@lau.edu.lb.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|November 21, 2021
PubMed

Insights

This review details COVID-19's impact on kidney health, covering inflammatory and noninflammatory kidney issues. It examines disease mechanisms and treatments, highlighting how medications may worsen renal damage.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic caused a global health crisis with significant mortality.
  • Kidney manifestations of COVID-19, both inflammatory and noninflammatory, are underrepresented in current literature.
  • Understanding these kidney issues is crucial for comprehensive patient care.

Purpose of the Study:

  • To review current knowledge on COVID-19-related kidney manifestations.
  • To explore the underlying pathologic mechanisms of these renal complications.
  • To analyze the impact of COVID-19 pharmacotherapies on kidney function.

Main Methods:

  • Systematic literature review of COVID-19 and kidney disease.
  • Analysis of pathological mechanisms linking SARS-CoV-2 infection to renal damage.
  • Evaluation of drug effects on kidney function in COVID-19 patients.

Main Results:

  • COVID-19 can cause diverse kidney problems, including acute kidney injury and glomerulopathy.
  • Viral infection and systemic inflammation contribute to kidney damage.
  • Certain medications used for COVID-19 may exacerbate pre-existing or induced renal impairment.

Conclusions:

  • COVID-19 poses a significant threat to kidney health through various mechanisms.
  • Pharmacotherapies for COVID-19 require careful consideration regarding their nephrotoxic potential.
  • Further research is needed to optimize treatment strategies and protect kidney function in COVID-19 patients.
Keywords:
AngiotensinCOVID-19InflammationKidneyRenal pathology

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