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Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention

Zuomin Hu1, Mengyuan Li1, Yunyun Cao1

  • 1Hunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, Central South University of Forestry and Technology, Changsha, Hunan, 410004, China.

Molecular Nutrition & Food Research
|November 21, 2021
PubMed

Insights

Dietary polyphenols show promise in cancer treatment by targeting cellular energy metabolism. These compounds regulate AMP-activated protein kinase (AMPK), a key energy regulator, to combat cancer development.

Area of Science:

  • Oncology
  • Metabolic pathways
  • Nutritional science

Background:

  • Cancer is a significant global health issue with complex metabolic alterations.
  • Cancer cells exhibit aberrant glucose metabolism, including high uptake and inefficient utilization.
  • AMP-activated protein kinase (AMPK) is crucial for energy metabolism and implicated in cancer development.

Purpose of the Study:

  • To review the role of dietary polyphenols in cancer prevention via the AMPK pathway.
  • To explain the anti-cancer effects of dietary polyphenols by interfering with cellular energy metabolism.
  • To summarize how polyphenols modulate AMPK activity and affect cancer-related pathways.

Main Methods:

  • Systematic review of current research on dietary polyphenols and the AMPK pathway in carcinogenesis.
  • Analysis of studies detailing the impact of polyphenols on cellular energy metabolism.
  • Summary of identified target molecules and pathways regulated by AMPK in response to polyphenols.

Main Results:

  • Dietary polyphenols demonstrate potential in preventing carcinogenesis by modulating the AMPK pathway.
  • Polyphenols interfere with cancer cell energy metabolism, offering an anti-cancer mechanism.
  • Specific pathways and target genes influenced by polyphenol-regulated AMPK activity were identified.

Conclusions:

  • Dietary polyphenols exert anti-cancer effects by targeting molecules regulated by AMPK.
  • Understanding polyphenol-AMPK interactions broadens knowledge of their anti-cancer mechanisms.
  • This review provides a valuable reference for research into novel anti-cancer strategies.
Keywords:
AMPKcancerdietary polyphenolsenergy metabolismmolecular mechanism

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