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DNAzyme-Functionalized Nanomaterials: Recent Preparation, Current Applications, and Future Challenges
Jabrane Jouha1,2, Hai Xiong1
1Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, China.
Small (Weinheim an Der Bergstrasse, Germany)
|November 21, 2021
Summary
DNAzyme-nanomaterial bioconjugates combine DNA enzymes and nanoparticles for advanced biomedical uses. This review details their preparation and applications in bioimaging, biosensing, and therapy.
Area of Science:
- Biotechnology
- Nanomedicine
- Materials Science
Background:
- DNAzyme-nanomaterial bioconjugates are emerging as versatile tools in biomedicine.
- These hybrids integrate catalytic DNA (DNAzymes) with various nanomaterials for enhanced functionality.
- Applications span bioimaging, biosensing, cancer therapy, and drug delivery.
Purpose of the Study:
- To review strategies for preparing DNAzyme-nanomaterial bioconjugates.
- To summarize recent applications of these advanced materials in biomedical fields.
- To discuss the advantages, drawbacks, and future directions of DNAzyme-nanomaterial research.
Main Methods:
- Functionalization of nanoparticles (NPs) like MOFs, AuNPs, GO, and MoS2 with DNAzymes.
- Synthesis and characterization of various DNAzyme-nanomaterial hybrids.
- Review of literature focusing on applications and performance.
Main Results:
- Detailed overview of DNAzymes conjugated with MOFs, AuNPs, GO, and MoS2.
- Representative examples of applications in bioimaging, biosensing, phototherapy, and drug delivery.
- Analysis of the benefits and limitations of current DNAzyme-nanomaterial systems.
Conclusions:
- DNAzyme-nanomaterial bioconjugates offer significant potential for diverse biomedical applications.
- Further research is needed to overcome existing challenges and optimize their performance.
- Future directions include exploring novel materials and refining therapeutic delivery systems.
