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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Immune-based combinations for metastatic triple negative breast cancer in clinical trials: current knowledge and

Alessandro Rizzo1,2, Angela Dalia Ricci1,2, Laura Lanotte2

  • 1Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italia.

Expert Opinion on Investigational Drugs
|November 22, 2021
PubMed
Abstract

Insights

Immune checkpoint inhibitor (ICI) monotherapy shows limited efficacy in metastatic triple-negative breast cancer (mTNBC). Combination strategies are being explored to improve immunotherapy response in mTNBC patients.

Area of Science:

  • Oncology
  • Immunotherapy
  • Breast Cancer Research

Background:

  • Immune checkpoint inhibitor (ICI) monotherapy is effective in a subset of metastatic triple-negative breast cancer (mTNBC) patients.
  • Enhancing immunotherapy efficacy is crucial for improving clinical outcomes in mTNBC.

Purpose of the Study:

  • To review current immune-based combination strategies for mTNBC.
  • To discuss future directions and ongoing clinical trials in mTNBC immunotherapy.

Main Methods:

  • Literature search conducted in October 2021.
  • Review of published clinical trials and abstracts from international cancer meetings.

Main Results:

  • ICI monotherapy benefits a minority of mTNBC patients.
  • Several immune-based combinations show promising results in recent studies.
  • Chemoimmunotherapy is approved for PD-L1 positive mTNBC.

Conclusions:

  • Combination therapies represent a key strategy to improve mTNBC treatment.
  • Novel ICI-based combinations are under investigation with anticipated results.
Keywords:
Breast cancercombinationsimmune checkpoint inhibitorsimmunotherapypembrolizumabsacituzumab govitecantriple negative breast cancer

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