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Green-synthetized selenium nanoparticles using berberine as a promising anticancer agent.

Mohamed S Othman1, Sofian T Obeidat2, Amal H Al-Bagawi3

  • 1Basic Sciences Department, Deanship of Preparatory Year, University of Ha'il, Hail 2240, Saudi Arabia; Faculty of Biotechnology, October University for Modern Science and Arts, Giza 12451, Egypt.

Journal of Integrative Medicine
|November 22, 2021
PubMed
Summary

Green-synthesized selenium nanoparticles (SeNPs) with berberine (Ber) show significant potential as an anticancer agent against Ehrlich solid tumors (ESTs). This novel combination therapy effectively reduced tumor size, improved survival rates, and modulated key apoptotic markers in mice.

Keywords:
ApoptosisBerberineEhrlich solid tumorOxidative stressSelenium nanoparticles

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Area of Science:

  • Nanotechnology
  • Biochemistry
  • Oncology

Background:

  • Selenium nanoparticles (SeNPs) exhibit chemo-preventative and therapeutic properties, with biogenic SeNPs offering enhanced biocompatibility and stability for medical applications.
  • Cancer therapy is a key area where SeNPs show promise, particularly when synthesized using biological methods.

Purpose of the Study:

  • To evaluate the antitumor potential of green-synthesized SeNPs using berberine (Ber) against Ehrlich solid tumors (ESTs).
  • To elucidate the mechanism of action of these SeNPs-Ber complexes in combating cancer.

Main Methods:

  • SeNPs were synthesized using berberine and sodium selenite (Na2SeO3), forming SeNPs-Ber complexes.
  • Ehrlich solid tumor (EST) bearing mice were treated with SeNPs-Ber (0.5 mg/kg), berberine alone (20 mg/kg), cisplatin (5 mg/kg), or left untreated (EST control).
  • Tumor size, body weight, survival rates, oxidative stress markers, gene expression (Bcl-2, Bax, caspase-3), and histopathological changes were analyzed.

Main Results:

  • SeNPs-Ber treatment significantly improved survival rates and reduced tumor size and body weight compared to the EST group.
  • SeNPs-Ber effectively reduced oxidative stress by decreasing lipid peroxidation and nitric oxide, and increasing glutathione levels.
  • Apoptosis was induced by SeNPs-Ber through downregulation of Bcl-2 and upregulation of Bax and caspase-3, alongside improved tumor tissue histology.

Conclusions:

  • Green-synthesized SeNPs using berberine represent a promising anticancer agent for Ehrlich solid tumors.
  • These SeNPs-Ber complexes hold potential for use as standalone or supplementary therapy in cancer treatment.