Related Experiment Video
Updated: Oct 12, 2025
08:20
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
6.5K
Bioactive toothpastes in dentin hypersensitivity treatment: A systematic review
Samantha Ariadne Alves de Freitas1, Neurinéia Margarida Alves de Oliveira1, Juliana Larocca de Geus2
1School of Dentistry, Federal University of Maranhão (UFMA), São Luís, Maranhão, Brazil.
The Saudi Dental Journal
|November 22, 2021
Summary
Bioactive glass in toothpaste effectively treats dentin hypersensitivity (DH) by forming a protective barrier. This systematic review confirms its efficacy for both at-home and in-office dental treatments.
Area of Science:
- Dentistry
- Biomaterials Science
- Regenerative Medicine
Background:
- Dentin hypersensitivity (DH) is a prevalent dental condition.
- Bioactive materials offer a novel approach to DH treatment by stimulating dentin remineralization and barrier formation.
- The clinical effectiveness of bioactive glass for DH requires systematic evaluation.
Purpose of the Study:
- To systematically review randomized controlled trials (RCTs) evaluating the efficacy of bioactive glass dentifrices in treating DH in adult patients.
- To compare the effectiveness of bioactive glass treatments applied at-home versus in-office.
Main Methods:
- Systematic review registered with PROSPERO, adhering to PRISMA guidelines.
- Comprehensive search of multiple databases (PubMed/Medline, CENTRAL, Web of Science, LILACS) and gray literature.
- Inclusion of RCTs with no language or publication date restrictions; risk of bias assessment performed.
Main Results:
- Fifteen studies were included in the final analysis after excluding duplicates and unrelated articles.
- Seven studies were assessed as low risk of bias, four as moderate, and four as high risk.
- Bioactive compounds demonstrated efficacy in treating DH at low concentrations (2.5-7.5%).
Conclusions:
- Bioactive glass is an effective treatment for dentin hypersensitivity.
- Low concentrations (2.5-7.5%) of bioactive compounds are sufficient for DH treatment.
- The findings support the use of bioactive glass for both at-home and in-office DH management.
