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Host variations in SARS-CoV-2 infection
Doruk Altiok1, Elif Zeynep Savci1, Büşra Özkara1
1Faculty of Dentistry, Başkent University, Ankara Turkey.
Turkish Journal of Biology = Turk Biyoloji Dergisi
|November 22, 2021
Summary
Host genetic variations, specifically polymorphic variants in host proteins, significantly impact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Coronavirus Disease 2019 (COVID-19) progression. Understanding these genetic factors is crucial for diagnosis and treatment strategies.
Area of Science:
- Genetics
- Immunology
- Virology
Background:
- The precise mechanisms of host-pathogen interaction in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain incompletely understood.
- Factors such as age, sex, race, blood type, and host genetic polymorphisms are implicated in Coronavirus Disease 2019 (COVID-19) progression and severity.
- The interplay between these factors and their collective influence on COVID-19 outcomes requires further elucidation.
Purpose of the Study:
- To investigate the specific impact of polymorphic variants in host proteins on the pathogenesis of Coronavirus Disease 2019 (COVID-19).
- To explore how these host genetic variants influence current diagnostic and therapeutic approaches for COVID-19.
- To identify potential modifications in diagnostic and treatment strategies based on host genetic variability.
Main Methods:
- Literature review and meta-analysis of studies examining host genetic polymorphisms and COVID-19.
- Analysis of existing data on protein-pathogen interactions relevant to SARS-CoV-2.
- Comparative analysis of diagnostic and treatment outcomes across different host genetic profiles.
Main Results:
- Certain host protein polymorphisms are demonstrably linked to variations in COVID-19 susceptibility and disease severity.
- These genetic variants can affect the efficacy of diagnostic tests and the response to specific COVID-19 treatments.
- The interwoven nature of epidemiological and genetic factors complicates a singular understanding of disease progression.
Conclusions:
- Host genetic variations, particularly in proteins involved in viral entry or immune response, are critical determinants of COVID-19 outcomes.
- Personalized medicine approaches considering host polymorphisms may enhance diagnostic accuracy and therapeutic effectiveness for COVID-19.
- Further research into host-pathogen genetic interactions is essential for optimizing COVID-19 management strategies.
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