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Related Experiment Video

Updated: Oct 12, 2025

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

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Published on: December 7, 2012

Improvement of Blood Processing and Safety by Automation and Pathogen Reduction Technology.

Ana Isabel Pérez Aliaga¹, Gorka Labata², Alfonso Aranda¹

¹Blood Bank and Tissues of Aragón, Zaragoza, Spain.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie

|November 22, 2021

Summary

Automation and pathogen reduction technology improved blood processing efficiency and safety. The Reveos system and Mirasol pathogen reduction technology (PRT) system decreased discard rates and enhanced blood component quality, ensuring self-sufficiency and safety.

Keywords:

Automation Blood processing Pathogen reduction technology Safety

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Last Updated: Oct 12, 2025

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Area of Science:

Transfusion Medicine
Blood Banking Technology
Biotechnology

Background:

The Blood and Tissues Bank of Aragon evaluated the Reveos® Automated Blood Processing System and Mirasol® Pathogen Reduction Technology (PRT) System.
A retrospective comparison of routine quality data from two distinct periods was conducted.

Purpose of the Study:

To describe the experience of implementing automated blood processing and pathogen reduction technology.
To compare the quality of blood components processed using traditional methods versus automated systems with PRT.

Main Methods:

Quality data from 6,525 blood components (2007-2012, semi-automated buffy coat) were compared with 6,553 components (2014-2019, Reveos and Mirasol systems).
Key quality indicators including discard rates, hemoglobin and hematocrit levels, platelet yields, and factor VIII levels were analyzed.

Main Results:

The Reveos system decreased whole blood discard rates (1.2% to 0.1%) and increased hemoglobin and hematocrit in red blood cell concentrates.
Platelet concentrate yields remained similar, but preparation methods evolved. Mirasol PRT treatment reduced PC expiry rates to 1.2% and eliminated septic transmissions.
Factor VIII levels in plasma were higher with the Reveos system.

Conclusions:

Automation via the Reveos system standardized and improved blood processing efficiency.
The implementation of Mirasol PRT was facilitated by resources freed through automation.
The combined technologies ensured blood supply self-sufficiency and enhanced blood safety, evidenced by zero septic transmissions with PRT-treated components.