Related Experiment Video
Updated: Oct 12, 2025
09:40
Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
5.8K
Non-Coding RNAs in Glioma Microenvironment and Angiogenesis
Dongxue Li1,2, Zhe Zhang3, Chengyu Xia2
1Intelligent Pathology Institute, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Frontiers in Molecular Neuroscience
|November 22, 2021
Summary
Non-coding RNAs (ncRNAs) are key regulators of blood vessel formation in glioma, a deadly brain tumor. Understanding ncRNA roles offers new therapeutic strategies for anti-angiogenic treatment.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Cancer Research
Background:
- Glioma, particularly glioblastoma, represents the most prevalent and fatal brain tumor.
- Tumor angiogenesis in glioma is complex, influenced by intratumoral heterogeneity and regulated by diverse cellular and molecular mechanisms within the tumor microenvironment.
- Non-coding RNAs (ncRNAs) are emerging as critical regulators of glioma angiogenesis, acting both intracellularly and extracellularly.
Purpose of the Study:
- To review the production, delivery, and functional roles of ncRNAs in the glioma tumor microenvironment.
- To elucidate the molecular mechanisms by which ncRNAs regulate glioma angiogenesis.
- To discuss the potential of ncRNA-based therapeutic strategies for anti-angiogenic therapy in glioma.
Main Methods:
- Literature review of recent studies on ncRNAs and glioma angiogenesis.
- Analysis of molecular mechanisms involved in ncRNA-mediated regulation of angiogenesis.
- Examination of ncRNA-based therapeutic approaches for glioma treatment.
Main Results:
- ncRNAs are integral to the regulation of glioma angiogenesis, produced and delivered through various mechanisms within the tumor microenvironment.
- Specific ncRNAs modulate key signaling pathways controlling blood vessel formation in gliomas.
- Dysregulation of ncRNAs contributes to tumor vascularization and progression.
Conclusions:
- ncRNAs play a significant role in regulating glioma angiogenesis.
- Targeting ncRNAs presents a promising avenue for developing novel anti-angiogenic therapies for glioma.
- Further research into ncRNA function and delivery is crucial for clinical translation.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
01:22MicroRNAs
3.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.2K
01:24Regulation of Angiogenesis and Blood Supply
2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
02:17The Tumor Microenvironment
7.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.0K
02:15Experimental RNAi
6.4K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.4K
01:23RNA Interference
26.7K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
26.7K