Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?
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Updated: Oct 13, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Patricia Martin-Romano1, Julien Adam2, Jean-Yves Scoazec2
1Early Drug Development Department (DITEP), Gustave Roussy Cancer Campus, Villejuif, France.
Abstract:
Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.
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