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Risk of Mucormycosis in Diabetes Mellitus: A Systematic Review

Manish Khanna1, Sabitha Challa2,3, Ahmed S Kabeil4

  • 1Internal Medicine/Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Cureus
|November 22, 2021
PubMed

Insights

Diabetes mellitus (DM) increases the risk of mucormycosis, a severe fungal infection. Prompt diagnosis and treatment are crucial for diabetic patients due to weakened immunity.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Mycology

Background:

  • Diabetes mellitus (DM), characterized by hyperglycemia, is a growing global health concern.
  • Insulin deficiency or resistance impairs sugar metabolism, leading to widespread health issues.
  • Diabetics have compromised immune systems, elevating susceptibility to infections, particularly fungal ones.

Purpose of the Study:

  • To review existing literature on the association between diabetes mellitus and mucormycosis.
  • To highlight the increased risk and potential severity of mucormycosis in diabetic patients.

Main Methods:

  • A comprehensive literature review was conducted.
  • Data were sourced from 19 published articles retrieved from PubMed and Google Scholar.
  • Inclusion and exclusion criteria were applied to select relevant studies.

Main Results:

  • The review confirmed a significantly increased risk of mucormycosis in patients with diabetes mellitus.
  • Mucormycosis poses severe, potentially fatal complications in diabetic individuals if not treated promptly.

Conclusions:

  • Diabetes mellitus is a critical risk factor for developing mucormycosis.
  • Early detection and timely management are essential to improve outcomes for diabetic patients with this fungal infection.
Keywords:
black fungusdiabetes mellitusdiabetes mellitus and immunitymanagement of mucormycosismucormycosis

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