Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Triple-Negative Breast Cancer (TNBC) is an aggressive subtype known for developing resistance to radiotherapy.
• Radiotherapy resistance in TNBC is a complex process influenced by cell metabolism and gene expression regulators.
• Non-coding RNAs play a critical role in regulating cellular responses to DNA damage and therapy.

Purpose of the Study:

• To review the role of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in Triple-Negative Breast Cancer (TNBC) radioresistance.
• To explore how these regulatory RNAs impact DNA damage response, cell death, and cell cycle regulation in TNBC.
• To identify potential therapeutic targets and biomarkers within regulatory RNA networks for TNBC.

Main Methods:

• Literature review focusing on regulatory non-coding RNAs (miRNAs and lncRNAs) and their involvement in TNBC radioresistance.
• Analysis of studies investigating the mechanisms by which miRNAs and lncRNAs affect cellular responses to ionizing radiation.
• Identification of specific regulatory RNAs and their targeted pathways or proteins.

Main Results:

• Regulatory RNAs, including miRNAs and lncRNAs, are significantly involved in DNA damage response, cell death, and cell cycle regulation in TNBC.
• Specific regulatory RNAs like miR-139-5p, the miR-15 family, and HOTAIR lncRNA, modulate multiple pathways simultaneously.
• Several regulatory RNAs target key proteins such as CHK1 and WEE1, highlighting complex regulatory axes.

Conclusions:

• Understanding miRNA/lncRNA/mRNA regulatory axes is crucial for deciphering TNBC radioresistance.
• Identified miRNAs and lncRNAs show potential as molecular markers for TNBC prognosis.
• These regulatory RNAs represent promising targets for novel therapeutic strategies to improve TNBC treatment outcomes.