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ARID1A Mutation in Metastatic Breast Cancer: A Potential Therapeutic Target

Xuan Cheng1,2,3,4, Jian-Xiong Zhao1,2,3,4, Feng Dong5,6

  • 1The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.

Frontiers in Oncology
|November 22, 2021
PubMed

Insights

Mutations in ARID1A, a key gene in breast cancer, are linked to poor survival and drug resistance. Understanding ARID1A function offers new therapeutic strategies for metastatic breast cancer patients.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Distant metastasis is the primary cause of breast cancer mortality.
  • Targeting specific mutations in advanced breast cancer can improve treatment efficacy.
  • ARID1A mutations are prevalent in metastatic breast cancer and affect SWI/SNF complex function.

Purpose of the Study:

  • To review ARID1A mutation profiles in metastatic breast cancer.
  • To elucidate the structure and function of ARID1A and the SWI/SNF complex.
  • To discuss ARID1A's role in endocrine resistance and its therapeutic potential.

Main Methods:

  • Literature review of ARID1A mutations in metastatic breast cancer.
  • Analysis of SWI/SNF complex function and ARID1A's role in gene regulation.
  • Exploration of mechanisms underlying ARID1A-mediated drug resistance.

Main Results:

  • Low ARID1A expression correlates with poor survival in luminal A and HER2-rich breast cancer.
  • ARID1A is crucial for maintaining luminal characteristics and predicting treatment response.
  • ARID1A alterations present therapeutic vulnerabilities and potential drug resistance.

Conclusions:

  • ARID1A mutations are significant in metastatic breast cancer, impacting survival and treatment response.
  • Further research into ARID1A is needed to overcome drug resistance and metastasis.
  • Targeting ARID1A pathways may offer novel therapeutic strategies for breast cancer.
Keywords:
ARID1ASWI/SNF complexendocrine resistancemetastatic breast cancersynthetic lethalitytherapeutic targets

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