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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

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Contribution of miRNAs in the Pathogenesis of Breast Cancer

Soudeh Ghafouri-Fard1, Ali Khanbabapour Sasi2, Atefe Abak3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Oncology
|November 22, 2021
PubMed

Insights

MicroRNAs (miRNAs) play a key role in breast cancer development and progression. Targeting these small molecules offers potential therapeutic strategies and non-invasive diagnostic tools for breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a leading cancer diagnosis in women, characterized by genomic heterogeneity.
  • Gene expression profiling reveals numerous gene alterations in breast cancer.
  • MicroRNAs (miRNAs) are emerging as critical regulators in breast carcinogenesis.

Purpose of the Study:

  • To explore the role of miRNAs in breast cancer development.
  • To investigate the potential of miRNAs as therapeutic targets.
  • To assess miRNAs as non-invasive diagnostic biomarkers for breast cancer.

Main Methods:

  • Review of current literature on miRNA function in breast cancer.
  • Analysis of gene expression data related to miRNA deregulation.
  • Evaluation of miRNA involvement in key cancer processes like apoptosis and metastasis.

Main Results:

  • miRNAs are implicated in modulating apoptosis, autophagy, and epithelial-mesenchymal transition.
  • miRNAs can influence chemotherapy resistance in breast cancer.
  • miRNAs are detectable in peripheral blood, suggesting diagnostic potential.

Conclusions:

  • miRNA expression modulation presents a promising therapeutic avenue for breast cancer.
  • miRNAs hold significant potential as non-invasive biomarkers for early breast cancer detection.
Keywords:
apoptosisbiomarkerbreast cancermiRNAmicroRNA

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