An approach to the stereoselective synthesis of Sp-dinucleoside phosphorothioates using phosphotriester chemistry

R Cosstick1, D M Williams

  • 1Robert Robinson Laboratories, Department of Organic Chemistry, University of Liverpool, UK.

Nucleic Acids Research
|December 10, 1987
PubMed

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Phosphodiester Linkages

Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...