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Related Experiment Video

Updated: Oct 12, 2025

BioMEMS and Cellular Biology: Perspectives and Applications

BioMEMS and Cellular Biology: Perspectives and Applications

Published on: October 1, 2007

Regenerative Engineering: Current Applications and Future Perspectives.

Dana Goldenberg^1,2, Caroline McLaughlin^1,2, Srinivas V Koduru^1,2

¹Irvin S. Zubar Plastic Surgery Research Laboratory, Penn State College of Medicine, Hershey, PA, United States.

Frontiers in Surgery

|November 22, 2021

Summary

This summary is machine-generated.

Regenerative engineering aims to create biological replacements for damaged tissues and organs, but clinical success is limited. Future advancements in materials and methods will enable more complex tissue fabrication.

Keywords:

engineering regeneration surgery tissue dysfunction transplantation

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Tissue Engineering

Background:

Many diseases and injuries lack effective treatments with current medicine and surgery.
Regenerative engineering offers a promising interdisciplinary approach to develop biological replacements.
The demand for bioengineered tissues spans all surgical specialties.

Purpose of the Study:

To review current methodologies in regenerative engineering.
To highlight clinical achievements and persistent challenges.
To discuss future perspectives in the field of tissue fabrication.

Main Methods:

Review of existing literature on regenerative engineering.
Analysis of current materials, methods, and technologies.
Examination of clinical translation successes and limitations.

Main Results:

Clinical translation is currently restricted to small, thin, or acellular constructs.
Vascularization and other factors impede the development of thicker tissues.
Existing technologies provide a foundation for future complex tissue engineering.

Conclusions:

Regenerative engineering holds significant potential for treating untreatable conditions.
Overcoming barriers like vascularization is crucial for advancing the field.
Continued innovation in materials and methods will drive future clinical applications.