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Related Experiment Video

Updated: Oct 12, 2025

Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo
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Remote Optogenetics Using Up/Down-Conversion Phosphors.

Takanori Matsubara1, Takayuki Yamashita1

  • 1Department of Physiology, Fujita Health University School of Medicine, Toyoake, Japan.

Frontiers in Molecular Biosciences
|November 22, 2021
PubMed
Summary

New optogenetics methods use phosphors for remote, wireless control of cellular functions. This approach overcomes limitations of invasive fiber optics and visible light scattering for potential clinical applications.

Keywords:
X-raysbehaviornear-infraredoptogeneticsrhodopsinscintillatorupconversionwireless

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Last Updated: Oct 12, 2025

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Area of Science:

  • Neuroscience
  • Material Science
  • Biotechnology

Background:

  • Optogenetics commonly uses microbial rhodopsins sensitive to visible light.
  • Visible light penetration in tissue is limited, hindering deep-brain optogenetic control.
  • Current invasive fiber-optic methods pose challenges for researchers and clinical translation.

Purpose of the Study:

  • To review recent advances in non-invasive optogenetic control technologies.
  • To discuss the potential of up- or down-conversion phosphors for remote cellular stimulation.
  • To explore future perspectives for clinical applications of wireless optogenetics.

Main Methods:

  • Review of recent scientific literature on advanced optogenetic techniques.
  • Analysis of material science applications in neuroscience for remote stimulation.
  • Discussion of up- and down-conversion phosphor technologies for optogenetics.

Main Results:

  • Emerging technologies enable remote optogenetic control using phosphors.
  • These methods offer a less invasive alternative to traditional fiber optics.
  • Progress is being made toward wireless and non-invasive cellular control.

Conclusions:

  • Non-invasive optogenetics using phosphors shows promise for future applications.
  • Further research is needed to overcome current limitations for clinical translation.
  • These advancements could revolutionize cellular function control in deep tissues.