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Related Experiment Video

Updated: Oct 12, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
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SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to

Alona Kuzmina1, Seraj Wattad1, Yara Khalaila2

  • 1The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Iscience
|November 22, 2021
PubMed
Summary
This summary is machine-generated.

The BNT162b2 vaccine neutralizes SARS-CoV-2 Kappa and Delta variants, though Delta shows higher infectivity. Delta plus variant demonstrates significant resistance to post-vaccination sera.

Keywords:
ImmunologyVirology

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Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Kappa and Delta variants rapidly became globally dominant.
  • Understanding their infectivity and sensitivity to existing vaccines is crucial.

Purpose of the Study:

  • To assess the neutralization potential of sera from individuals who recovered from SARS-CoV-2 or received the BNT162b2 vaccine against Kappa and Delta variants.
  • To compare the infectivity and neutralization sensitivity of these variants.

Main Methods:

  • Monitoring neutralization of SARS-CoV-2 Kappa and Delta pseudoviruses using convalescent and BNT162b2 post-vaccination sera.
  • Assessing infectivity levels of variants compared to wild-type SARS-CoV-2.

Main Results:

  • Both Kappa and Delta variants were neutralized by sera, with a mild decrease in sensitivity.
  • The Delta variant exhibited higher infectivity than Kappa or wild-type SARS-CoV-2.
  • The Delta plus variant (AY.1/B.1.617.2.1) showed high resistance to post-vaccination sera, comparable to the Beta variant, but with infectivity similar to wild-type.

Conclusions:

  • The BNT162b2 vaccine remains effective against circulating Delta variants, explaining the Delta variant's prevalence.
  • While Delta is more infectious, it is less resistant to vaccine-induced immunity than the Beta variant.
  • Delta plus variant poses a potential concern due to its high resistance to vaccine-induced neutralization.