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Published on: September 20, 2020
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Loco-regional intervention for hepatocellular carcinoma
1Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Journal of Interventional Medicine
|November 22, 2021
Summary
Locoregional therapies offer effective treatment for hepatocellular carcinoma (HCC) patients ineligible for surgery. These treatments manage tumors within the liver, improving outcomes when transplantation or resection is not possible.
Area of Science:
- Hepatobiliary Medicine
- Oncology
- Interventional Radiology
Background:
- Hepatocellular carcinoma (HCC) often precludes surgical options due to tumor characteristics or patient comorbidities.
- Liver transplantation is limited by donor availability, leaving many patients without curative options.
- Without timely intervention, HCC prognosis is generally poor, with patients succumbing to liver failure.
Purpose of the Study:
- To highlight the role of locoregional therapies in managing HCC.
- To discuss the efficacy of locoregional therapies for patients unsuitable for surgery.
- To position locoregional therapies as a competitive primary treatment for small HCC.
Main Methods:
- Review of locoregional therapies for HCC management.
- Analysis of HCC's intrahepatic growth pattern and suitability for local treatment.
- Comparison of locoregional therapy outcomes with surgical and transplantation options.
Main Results:
- Locoregional therapies serve as effective tools for palliation, tumor down-staging, and bridging to transplantation.
- Local ablative therapy is emerging as a primary treatment option for small HCC.
- HCC's tendency to remain intrahepatic makes it well-suited for locoregional treatment strategies.
Conclusions:
- Locoregional therapies significantly impact HCC patients ineligible for surgery.
- Effective local-regional treatment can improve survival by managing intrahepatic tumor burden.
- Locoregional approaches address the primary cause of mortality in HCC: liver failure.
