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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

100
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
100
Pathophysiology of Heart Failure01:17

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Related Experiment Video

Updated: Oct 12, 2025

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
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Hemodynamic stress and microscopic remodeling.

Fatih Yalçin1, Hulya Yalçin1, Roselle Abraham1

  • 1UCSF HEALTH, Department of Cardiology, University of California San Francisco, San Francisco, CA, USA.

International Journal of Cardiology. Cardiovascular Risk and Prevention
|November 22, 2021
PubMed
Summary
This summary is machine-generated.

Sympathetic drive significantly impacts the heart, particularly the left ventricular (LV) base. Early detection of basal septal hypertrophy (BSH) aids in recognizing hypertensive heart disease remodeling.

Keywords:
Adaptive phaseBasal septal hypertrophyHemodynamic stressHypertensionRemodeling

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Area of Science:

  • Cardiovascular Physiology
  • Cardiac Remodeling
  • Hypertensive Heart Disease

Background:

  • The heart responds to various conditions, with sympathetic drive playing a crucial role.
  • The left ventricular (LV) base is disproportionately affected by sympathetic drive and wall stress during pressure-overload remodeling.
  • Basal septal hypertrophy (BSH) is linked to the early stages of hypertensive heart disease.

Purpose of the Study:

  • To investigate the role of sympathetic drive in cardiac remodeling.
  • To understand the early changes in the left ventricle due to pressure-overload.
  • To highlight the significance of basal septal hypertrophy in hypertensive heart disease.

Main Methods:

  • Analysis of cross-sectional data showing basal septal hypertrophy.
  • Utilizing 3rd generation microscopic ultrasound in small animal models.
  • Evaluating hemodynamic stress and its impact on septal wall exposure.

Main Results:

  • Basal septal hypertrophy (BSH) is associated with the early phase of hypertensive heart disease.
  • BSH can be detected under various stress stimuli due to its proximity to increased afterload.
  • Advanced cases may show significant septal hypertrophy from prolonged hemodynamic stress exposure.

Conclusions:

  • Geometric and functional evaluation of initial remodeling from hemodynamic stress is vital.
  • Findings support early recognition of the adaptive phase of hypertensive remodeling.
  • Timely management strategies can be developed based on these early indicators.